[GRADE ÀÌ¿ÜÀÇ ±Ù°Å¼öÁØ (level of evidence) ºÐ·ù¹ý]

[1. À¯¹æ¾Ï Áø·á±Ç°í¾È(2008)ÀÇ level of evidence]

- Level 1: ¸ðµç ¹«ÀÛÀ§ ´ëÁ¶½ÃÇè(randomized controlled trial: RCT)À» ü°èÀûÀ¸·Î °ËÅä(systemic review: SR)ÇÏ¿© ¾òÀº ±Ù°Å

- Level 2: ÀûÀýÇÏ°Ô °í¾ÈµÈ Çϳª ÀÌ»óÀÇ ¹«ÀÛÀ§ ´ëÁ¶½ÃÇè¿¡¼­ ¾òÀº ±Ù°Å

- Level 3:Àß °í¾ÈµÈ ´ëÁ¶½ÃÇè(controlled trial: CT)¿¡¼­ ¾òÀº ±Ù°ÅÀ̰ųª, ´Ù±â°ü¿¡¼­ ½ÃÇàÇÑ ÄÚȣƮ ¶Ç´Â ȯÀÚ´ëÁ¶¿¬±¸¿¡¼­ ¾òÀº ±Ù°Å, ȤÀº °³ÀÔ(intervention)¾øÀÌ ¿¬¼ÓÀû ¿¬±¸¿¡¼­ ¾òÀº ±Ù°Å

- Level 4: ±ÇÀ§ ÀÖ´Â Àü¹®°¡ÀÇ ÀÓ»ó°æÇè¿¡ ±âÃÊÇÑ ÀÇ°ßÀ̳ª, Àü¹®°¡·Î ±¸¼ºµÈ À§¿øȸ¿¡¼­ ¹ßÇ¥µÈ ¿¬±¸°á°ú³ª º¸°í ÀÚ·á¿¡¼­ ¾òÀº ±Ù°Å


[2. SIGN (Scottish Intercollegiate Guideline Network)ÀÇ level of evidence]

- 1++: High quality meta-analyses, systematic reviews, or RCTs with a very low risk of bias

- 1+: Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias

- 1: Meta-analyses, systematic reviews, or RCTs with a high risk of bias

- 2++: High quality systematic reviews of case control or cohort studies. High quality case control or cohort studies with a very low risk of confounding or bias and a high probability that the relationship is causal

- 2+: Well-conducted case control or cohort studies with a low risk of confounding or bias and a moderate probability that the relationship is causal

- 2: Case control or cohort studies with a high risk of confounding or bias and a significant risk that the relationship is not causal

- 3: Non-analytic studies, e.g. case reports, case series

- 4: Expert opinion


[3. NICE ´ëÀå¾Ï ¸Å´º¾ó(2004)ÀÇ level of evidence] - GRADE ¹æ¹ý·ÐÀÌ Á¦¾ÈµÇ±â Àü±îÁö EnglandÀÇ NICE¿¡¼­ »ç¿ëÇÏ¿´´ø ¹æ¹ýÀ¸·Î »ý°¢µÊ.

- A. Evidence derived from randomised controlled trials or systematic reviews of randomized trials.

- B. Evidence from non-randomised controlled trials or observational studies.

- C. Professional consensus


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