[Conceptual model of histological differentiation of EGC]

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This is my conceptual model of histological differentiation of early gastric cancer. There are two dominant types of histology. One is differentiated type, and the other is undifferentiated type. However, there are a lot of cases in the middle. We doní»t know exactly how many patients are included in this mixed area.

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Usually, the histological grouping is made by the major area of histological differentiation. For example, if 70 percent of area shows undifferentiated histology, we call it undifferentiated type of early gastric cancer like the blue arrow. If 80 percent of area shows undifferentiated histology, we call it differentiated type of early gastric cancer like the red arrow.

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The concept of histological heterogeneity comes from this area. EGC cases mixed with undifferentiated component less than 50 percent of area can be called as histological heterogeneity.ts.

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