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[20110530. Issues on duodenal ulcer (12): selection of medication for maintenance treatment (continued)]

¾îÁ¦ ¸»¾¸µå¸° ¹Ù¿Í °°ÀÌ Àú´Â Ç︮ÄÚ¹ÚÅÍ Á¦±ÕÄ¡·á ¿©ºÎ¿Í ¹«°üÇÏ°Ô À¯Áö¿ä¹ýÀ¸·Î H2RA ´ë½Å PPI¸¦ ¾²°í ÀÖ½À´Ï´Ù. ±×°Íµµ ÀÌƲ¿¡ Çѹø half dose·Î ¾²°í ÀÖ½À´Ï´Ù.

¼ÒÈ­¼º±Ë¾çÀÇ Àç¹ß¹æÁö À¯Áö¿ä¹ýÀ¸·Î ÀÌƲ¿¡ Çѹø PPI¸¦ ¾´´Ù´Â ¹®ÇåÀº ¾ÆÁ÷ ãÁö ¸øÇß½À´Ï´Ù. ´ë½Å 2004³â Ohara°¡ Á¦±ÕÄ¡·á ÈÄ Àç¹ßÇÑ Hp À½¼º ±Ë¾ç¿¡¼­ Ç¥ÁØ¿ë·® PPI¸¦ ÀÏÁÖÀÏ¿¡ ÀÌƲ (Åä¿äÀÏ°ú ÀÏ¿äÀÏ) »ç¿ëÇÏ´Â ¹æ¹ýÀÌ È¿°úÀûÀ̶ó°í ¹ßÇ¥ÇÑ °ÍÀº º¸¾Ò½À´Ï´Ù. ±×·¯³ª ¿ì¸® Á¤¼­¿¡´Â ÁÖ¸»¿¡¸¸ ¾àÀ» ¸Ô°í ÁÖÁß¿¡´Â ¾È ¸Ô´Â ¹æ½Äº¸´Ù´Â ÀÌƲ¿¡ Çѹø ȤÀº ÀÏÁÖÀÏ¿¡ µÎ¹ø (¿ù¿äÀÏ°ú ¸ñ¿äÀÏ) º¹¿ëÇÏ´Â ¹æ½ÄÀÌ Àß ÅëÇÕ´Ï´Ù.

Second generation PPI half dose¸¦ »ç¿ëÇÏ´Â Á¦ ³ª¸§ÀÇ ±Ù°Å´Â ¾î¶² ³í¹®¿¡¼­ º» ´ÙÀ½°ú °°Àº ±ÛÀÔ´Ï´Ù. No additional benefit is to be gained from using a proton-pump inhibitor at a dose > 15 mg lansoprazole to prevent relapse (link). ¾î¶² ¼±»ý´ÔµéÀº second generation PPI ´ë½Å °¡°ÝÀÌ ½Ñ omeprazoleÀ» ¸ÅÀÏ ¾²±âµµ ÇÕ´Ï´Ù.


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