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[ADR of PPI - hypomagnesemia]

ÃÖ±Ù ¿©·¯ Áý´ãȸ¿¡¼­ ¾ð±ÞµÇ°í ÀÖ´Â PPI¿Í °ü·ÃµÈ Áß¿äÇÑ ºÎÀÛ¿ëÀº PPI °ü·Ã hypomagnesemiaÀÔ´Ï´Ù.

ã¾Æº¸´Ï ´ÙÀ½°ú °°ÀÌ ¾º¿© ÀÖ¾ú½À´Ï´Ù. "Hypomagnesemia cause symptoms of serious side effects in certain patients, such as muscle spasm (tetany), irregular heartbeat (arrhythmia) and convulsions (seizures), impaired parathyroid hormone secretion and hypocalcemia. The mechanism of occurrence of hypomagnesemia in the provision of long-term PPI is not known, but may be related to changes in intestinal absorption of magnesium."

°ü·ÃÇÏ¿© ½Ä¾àû ÀǾàÇ°¾ÈÀü¼º ¼­ÇÑÀÌ ¹ßÇàµÈ ¹Ù ÀÖ½À´Ï´Ù.

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PPI¿Í °ü·ÃµÈ hypomagnesemia´Â ±×¸® ÈçÇÑ °ÍÀº ¾Æ´Õ´Ï´Ù. ÀϺ»ÀÇ Ã¹ case reportµµ 2012³â¿¡¾ß ¹ßÇ¥µÇ¾ú½À´Ï´Ù. ºñ·Ï µå¹°Áö¸¸ »ý¸íÀ» À§ÇùÇÒ ¼ö ÀÖ´Â Áß¿ä ÇÕº´ÁõÀ¸·Î ÀÌÇØÇÏ¸é µÇ°Ú½À´Ï´Ù. ÀϺ» Áõ·ÊÀÇ ÃÊ·ÏÀ» ¿Å±é´Ï´Ù.

"Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral ankle arthritis, and tremor of the extremities who had convulsions 3 days after admission. Blood analysis showed severe hypomagnesemia. He had been taking rabeprazole (10 mg/day) for 5 years. After stopping rabeprazole and correcting the electrolytes imbalances, his symptoms improved without recurrence."

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