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[20120509. Terminology (3) - NERD and minimal change]

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ÀüÇüÀûÀÎ ¿ª·ù Áõ»óÀ» È£¼ÒÇÏ¿© Áõ»ó±â¹Ý GERD·Î Áø´ÜÇÑ È¯ÀÚ¿¡¼­ ³»½Ã°æ °Ë»ç¸¦ ½ÃÇàÇÏ¸é ¾à 50-60%¿¡¼­ ÇϺνĵµÀÇ mucosal break°¡ °üÂûµÇÁö ¾Ê½À´Ï´Ù. ÀÌ·± ȯÀÚ±ºÀ» non-erosive reflux disease (NERD)·Î ºÐ·ùÇÕ´Ï´Ù.

NERD¸¦ ³»½Ã°æ ¼Ò°ßÀ¸·Î Á¤»ó°ú minimal change·Î ³ª´©±âµµ ÇÕ´Ï´Ù. Minimal change¿¡ ´ëÇÏ¿© ÃÖÃÊÀÇ Ã¼°èÀûÀÎ ³íÀǸ¦ ÁøÇàÇÑ Armstrong (Gastroenterology 1996)Àº minimal change¸¦ ´ÙÀ½°ú °°Àº 7°³·Î ³ª´©¾î ±â¼úÇÏ¿´½À´Ï´Ù.

(1) Localized area(s) of erythema in one or more segments at mucosal junction
(2) Indistinctness or blurring of all part of mucosal junction
(3) Friability at the mucosal junction
(4) Diffuse erythema in distal esophagus
(5) Patchy erythema in distal esophagu
(6) Increased vascularity in distal esophagus
(7) Edema/accentuation of mucosal folds.

±×·¯³ª ÀÌ·¯ÇÑ ºÐ·ù°¡ ³Ê¹« º¹ÀâÇÏ°í inter-observation¿¡ ¹®Á¦°¡ À־ ±¹³»¿¡¼­ ÁøÇàµÈ ´Ù±â°ü ¿¬±¸ (Lee, et al. J Gastroenterol Hepatol 2008)¿¡¼­´Â white turbid discoloration°ú Z-line blurring¸¸À» minimal change·Î °£ÁÖÇÑ ¹Ù ÀÖ½À´Ï´Ù.

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