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[ESD for esophageal carcinoma in muscularis mucosa (M3) - to surgery or not]
Muscularis mucosa (M3) ½Äµµ¾ÏÀ¸·Î È®½ÅµÇ¸é ¼ö¼úÀ» º¸³»´Â °ÍÀÌ ¸Â´Ù°í »ý°¢ÇÕ´Ï´Ù. ±×·¯³ª M2ÀÏÁö M3ÀÏÁö Á¤È®È÷ ¾Ë ¼ö ¾ø´Â »óȲ¿¡¼ º´¼ÒÀÇ Å©±â°¡ ÀÛ´Ù¸é ESD¸¦ ½ÃµµÇÒ ¼ö ÀÖ½À´Ï´Ù. ±×·¯³ª ESD ÈÄ 'M3 ½Äµµ¾Ï ¿ÏÀüÀýÁ¦'¶ó´Â °á°ú¸¦ ¹Þ°Ô µÇ¸é Ç×»ó °í¹ÎÇÏ°Ô µË´Ï´Ù. ¼ö¼úÀ» ÇØ¾ß ÇÒ±î¿ä? ChemoRT¸¦ ÇØ¾ß ÇÒ±î¿ä? ±×³É Àß °üÂûÇÏ¸é µÇ´Â °ÍÀϱî¿ä?
Àú´Â M3 ½Äµµ¾Ï ¿ÏÀüÀýÁ¦ »óȲ¿¡¼ ¸²ÇÁÀý ÀüÀÌ À§ÇèÀÌ ³·´Ù°í ÆÇ´ÜµÇ¸é ¼ö¼úº¸´Ù´Â °æ°ú°üÂûÀ» ±ÇÇÏ°í ÀÖ½À´Ï´Ù. ChemoRT´Â ÇØ º» ÀûÀÌ ¾ø½À´Ï´Ù. µÑ Áß Çϳª È®½ÇÈ÷ ¼±ÅÃÇÏ´Â °ÍÀ» ¼±È£ÇÕ´Ï´Ù. ¿©·¯ºÐÀº ¾î¶»°Ô »ý°¢ÇϽʴϱî?
M3 ½Äµµ¾Ï ¿ÏÀüÀýÁ¦ »óȲ¿¡¼ º´¼Ò°¡ Å©°í, ÀýÁ¦º¯¿¬ÀÌ ÃæºÐÇÏÁö ¾Ê°í, ¸²ÇÁÀý ÀüÀÌ À§ÇèÀÌ ³ôÀº ÆíÀ̶ó¸é ¼ö¼úÀ» ±ÇÇϱ⵵ ÇÕ´Ï´Ù. ¾Æ·¡ ȯÀÚ´Â ESD¸¦ ½ÃÇàÇÏ¿´°í M3 ½Äµµ¾ÏÀ̳ª safety marginÀÌ ³Ë³ËÄ¡ ¸øÇß½À´Ï´Ù. ¿©·¯ºÐÀº ¾î¶»°Ô ÇϽðڽÀ´Ï±î?
- extension to muscularis mucosa without submucosal invasion (width: 2,000 um)
- lymphatic tumor emboli: not identified
- lateral resection margin: free from carcinoma (safety margin: 0.2 cm, 0.2 cm, 0.6 cm and 0.9 cm)
- negative but very close to deep margin (safety margin: 700 um)
Àú´Â ¼ö¼úÀ» ±ÇÇÏ¿´°í ÃÖÁ¾ ¼ö¼ú º´¸®°á°ú¿¡¼ residual tumor³ª ¸²ÇÁÀý ÀüÀÌ´Â ¾ø¾ú½À´Ï´Ù.
ÀÏÀü¿¡ º¸¿©µå¸° Áõ·Ê(20121225-EndoTODAY)ÀÌÁö¸¸ ´Ù½Ã Çѹø ¼Ò°³ÇÕ´Ï´Ù. ¸²ÇÁÀý ÀüÀÌ°¡ ÀÖ¾ú´ø Áõ·ÊÀ̱⠶§¹®ÀÔ´Ï´Ù.
ESD ÈÄ M3 ½Äµµ¾ÏÀ̾ú°í ÀýÁ¦º¯¿¬Àº À½¼ºÀ̾úÁö¸¸ endolymphatic tumor emboli°¡ º¸¿© ¼ö¼úÀ» ÇÏ¿´°í ¸²ÇÁÀý ÀüÀÌ°¡ È®ÀεǾú½À´Ï´Ù. Àú´Â ½Äµµ ESD¶ó´Â °ÍÀÌ »ç½Ç ¸Å¿ì ¾Æ½½¾Æ½½ÇÑ ½Ã¼úÀ̶ó´Â »ý°¢À» ¹ö¸± ¼ö ¾ø½À´Ï´Ù. ȯÀÚ¿¡°Ô Å« µµ¿òÀÌ µÇ´Â ½Ã¼úÀÎ °ÍÀº Ʋ¸²¾øÁö¸¸, ¾ÈÀüÇÏ°í È¿°úÀûÀÎ ½Ã¼úÀÌ µÇ±â À§Çؼ´Â ¹«Ã´ systemÀ» Àß °®Ãç¾ß ÇÑ´Ù´Â »ý°¢ÀÔ´Ï´Ù.
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