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[Q&A] Stomach other than peptic ulcer, cancer, EMR/ESD

Intestinal metaplasia?

[ºÎ»ê ¾Öµ¶ÀÚ Áú¹®] À§³»½Ã°æÀ» º¸´Ùº¸¸é, À§Á¡¸·ÀÌ ¸¶Ä¡ ´ëÀå¿ëÁ¾ÀÇ À¶¸ð»ó º¯È­Ã³·³ º¸ÀÌ´Â °æ¿ì°¡ Àִµ¥, ÀÓ»óÀûÀÎ Àǹ̰¡ ÀÖ´Â °ÍÀÎÁö¿ä? À§Á¡¸·Àº villi°¡ ¾ø°í, crypt°¡ ÀÖ´Â °ÍÀ¸·Î ¾Ð´Ï´Ù. À§Á¡¸·¿¡ ÀÌ·± À¶¸ð»ó º¯È­¸¦ º¸ÀÌ¸é ¼ÒÀå»óÇÇ·Î intestinal metaplasiaµÈ ºÎÀ§ÀÌÁö ¾ÊÀ»±î ÃßÃøÇÏ¿´´Âµ¥, »ý°ËÀ» ÇÏ¿© ¸ÅĪÇÏ¿© Á¦´ë·Î ºñ±³ÇÑ ÀûÀÌ ¾ø¾ú´ø °Í °°½À´Ï´Ù. »ý°ËÀ» Çصµ ¶§·Î´Â gastritis, ¶§·Î´Â intestinal metaplasia·Î º¸°íµÇ¾ú´ø °Í °°½À´Ï´Ù. adenoma´Â ¾ø¾ú´ø °Í °°½À´Ï´Ù. ±¹¼ÒÀûÀ¸·Î ȤÀº Á¦¹ý ³ÐÀº ¹üÀ§·Î ÀÌ·¯ÇÑ ¼Ò°ßÀ» º¸ÀÌ´Â °æ¿ì°¡ Á¾Á¾ ÀÖ¾î ±³¼ö´Ô ÀÇ°ß ±¸ÇÕ´Ï´Ù.

[ÀÌÁØÇà ´äº¯] ÁÁÀº Áú¹® °¨»çÇÕ´Ï´Ù. ¼±Á¾Àº ¾Æ´Ï¶ó´Âµ¥ µ¿ÀÇÇÕ´Ï´Ù. ´ëºÎºÐ À§¿°¿¡ ÀÇÇÑ ºñƯÀÌÀû ¼Ò°ßÀ̶ó°í »ý°¢ÇÏ°í ÀÖ½À´Ï´Ù. Àú´Â °³ÀÎÀûÀ¸·Î È­»ý¼º À§¿°À» Ãʱâ¼Ò°ßÀ̶ó°í º¸´Âµ¥ ¸íÈ®ÇÏÁö ¾Ê½À´Ï´Ù. ÀϺ»¿¡¼­´Â pit patternÀ¸·Î ³ª´©¾î ¿©·¯ À̾߱⸦ ÇÏ°í ÀÖÀ¸³ª º° ÀÇÀÇ´Â ¾ø´Ù°í º¾´Ï´Ù.


Primary antibodies to detect mucin and brush border in gastric mucosa

Primary antibody (clone>TargetSource
Muc2(CLH2)Goblet cellsNovocastra
Muc5AC(CLH5)Gastric foveolar epitheliumNovocastra
Muc6(Ccp58)Gastric pyloric glandNovocastra
CD10(56C6)Brush borderNovocastra

Reference: Korean J Helicobacter Up Gastrointest Res 2013;13:84-90


ESD for ectopic pancreas?

[2013-7-7. ¾Öµ¶ÀÚ(H´ë ±³¼ö)ÀÇ Áõ·Ê] ÃÖ±Ù SMT·Î ÃßÀû°üÂû(3rd layer¿¡ heterogenous hypoechoic lesion¿¡ ±âÀÎÇÏ´Â mass¿´À½)ÇÏ´Â Áß, 6°³¿ù ÈÄ ³»½Ã°æ °Ë»ç¿¡¼­ SMT Á߽ɺο¡ ±Ë¾çÀÌ ¹ß»ýÇÏ¿© malignant GIST ¹èÁ¦Çϱâ À§ÇØ ESD¸¦ ½ÃÇàÇÏ¿´°í ectopic pancreas·Î Áø´ÜµÈ Áõ·Ê°¡ ÀÖ¾î ¸ÞÀÏ µå¸³´Ï´Ù.


ù work dup


ÃßÀû°üÂû Áß ±Ë¾çÀÌ ¹ß»ýÇÏ¿© ESD ½ÃÇà

[2013-7-9. ÀÌÁØÇà ÀÇ°ß] ÁÁÀº Áõ·Ê °¨»çÇÕ´Ï´Ù. Ectopic pancreas¸¦ »çÀü¿¡ ¾Ë°í ESDÇÏ´Â °æ¿ì´Â µå¹°Áö¸¸ °£È¤ º¸¿©ÁֽŠÁõ·Ê¿Í °°Àº ÀÌÀ¯·Î ½ÃÇàµÇ±âµµ ÇÏ´Â °Í °°½À´Ï´Ù. º¸Åë ectopic pancrea ESD´Â ÁÖº¯ Á¶Á÷°ú adhesionÀÌ ½ÉÇØ ½Ã¼úÀÌ ¾î·Á¿î °ÍÀ¸·Î ¼Ò¹®ÀÌ ÀÚÀÚÇѵ¥, º» Áõ·Ê¿¡¼­ ºñ±³Àû ±ò²ûÇÏ°Ô Àß µÈ °Í °°½À´Ï´Ù. ¼ö°í ¸¹À¸¼Ì½À´Ï´Ù. ÁÁÀº Áõ·Ê °øÀ¯ÇØ Áּż­ °¨»çÇÕ´Ï´Ù.


Glivec (Gleevec) for GIST

[¾Öµ¶ÀÚ Áú¹®] ³²ÀÚ 57¼¼. ESRD·Î Åõ¼®À» ¹Þ°í °è½Å ºÐÀÔ´Ï´Ù. GIST·Î ¼ö¼úÀ» ÇÏ¿´½À´Ï´Ù. º´¸®´Â gastric GIST, Àå°æ 8.5cm, mitotic count <1/50 HPF, C-KIT ¾ç¼ºÀ̾ú´Âµ¥ glivecÀÌ º¸ÇèÀÌ µÉ±î¿ä? intermidiate riskÀε¥...

[2013-8-5. ÀÌÁØÇà ´äº¯] GlivecÀ̶ó°í ¾²¸é ¹Ì±¹¿¡¼­´Â '±Û¶óÀ̹é'À¸·Î ¹ßÀ½ÇÏ´Â Àǻ簡 ¸¹¾Æ¼­... ȸ»ç¿¡¼­´Â ³ª¶ó »çÁ¤¿¡ µû¶ó GlivecÀ¸·Î ½ÃÆÇÇϱ⵵ ÇÏ°í GleevecÀ¸·Î ½ÃÆÇÇϱ⵵ ÇÑ´ä´Ï´Ù. ¿Â°® °úÀ× Áø´Ü°ú °úÀ×Ä¡·á°¡ ³­¹«ÇÏ´Â ½Ã´ë¿¡... Àǻ簡 Àû´çÇÑ ±Ù°Å¸¦ °¡Áö°í Ä¡·á¸¦ ÇÏ°í ½Í¾îµµ ¸øÇÏ°Ô ¸¸µå´Â Á¦µµ´Â µµ´ëü ´©±¸¸¦ À§ÇÑ Á¦µµÀϱî¿ä? Á¦°¡ °ü·Ã ºÎ¼­¿¡ ¾Ë¾Æº¸¾Ò½À´Ï´Ù. ´ÙÀ½°ú °°Àº ´äº¯À» ¹Þ¾Ò½À´Ï´Ù.

½Ç¹«ÀÚ¿¡°Ô È®ÀÎ ÈÄ ´ä µå¸³´Ï´Ù. ´ë»óȯÀÚ´Â 2)¹ø »ç·Ê¿¡ ÇØ´çÇÒ °Í °°½À´Ï´Ù¸¸....
1) ÀüÀÌ°¡ À־ °í½ÄÀû ¿ä¹ýÀ¸·Î Àû¿ëÀÌ¸é º¸ÇèÀÌ µÇ±¸¿ä,
2) ÀüÀÌ°¡ ¾ø°í ¼ö¼ú ÈÄ º¸Á¶¿ä¹ýÀ¸¸¸ »ç¿ëÀ̸é high risk °¡ ¾Æ´Ï¾î¼­ º¸ÇèÀ¸·Î Àû¿ëµÇÁö ¾Ê½À´Ï´Ù.

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