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[CA-125 in Korean females with ascites]

Áö±Ý±îÁö »ï¼º¼­¿ïº´¿ø¿¡¼­ °æÇèÇÏ¿´´ø °áÇÙ¼º º¹¸·¿° 48¿¹¸¦ ºÐ¼®ÇÏ¿© ªÀº ±Û·Î ¸¸µé¾î Yonsei Medical Journal¿¡ Clinical Significance of Serum CA-125 in Korean Females with Ascites¶ó´Â Á¦¸ñÀ¸·Î ±â°íÇÏ¿´½À´Ï´Ù (Àü¹®º¸±â).

Purpose: Mycobacterium tuberculosis is endemic in Korea. Because tuberculous peritonitis is characterized by ascites, abdominal pain, abdominal mass and elevation of serum CA-125, it can be confused with ovarian malignancies. The aim of this study was to evaluate the significance of serum CA-125 level in the differential diagnosis of tuberculous peritonitis and ovarian malignancy in a Mycobacterium tuberculosis-endemic area.

Materials and Methods: The medical records of patients diagnosed with tuberculous peritonitis (n=48) or epithelial ovarian malignancy (n=370) at Samsung Medical Center from January 2000 to October 2009 were retrospectively reviewed.

Results: Median serum CA-125 level in the epithelial ovarian cancer group was significantly higher than that in the tuberculous peritonitis group (p¡Â0.01). Only one patient (2.1%) in the tuberculous peritonitis group had a serum CA-125 level over 2000 U/mL. However, 109 patients (29.5%) in the epithelial ovarian cancer group had a serum CA-125 level over 2000 U/mL. At the CA-125 ranges of 400 to 599 and 600 to 799, the proportions of those with tuberculous peritonitis were 24% and 21.9%, respectively. At a serum CA-125 level over 1000 U/mL, however, the proportion of tuberculous peritonitis was much lower (2.1%).

Conclusion: Tuberculous peritonitis should be considered in the evaluation of female patients with ascites and high serum CA-125.


Ç÷û CA-125ÀÇ ºÐÆ÷ÀÔ´Ï´Ù. °áÇÙ¼º º¹¸·¿°¿¡¼­´Â ¾îÁ¦ÀÇ Áõ·Ê°¡ °¡Àå ³ô¾Æ 2,702¿´½À´Ï´Ù. ±×·¯³ª 1,000 ÀÌ»óÀÌ¸é ´ëºÎºÐ ³­¼Ò¾ÏÀ̾ú½À´Ï´Ù. ³­¼Ò¾Ï¿¡¼­ Æò±Õ CA-125Ä¡´Â 1,002¿´°í °áÇÙ¼º º¹¸·¿°¿¡¼­´Â 418À̾ú½À´Ï´Ù.


CA-125 ¿µ¿ªº° °áÇÙ¼º º¹¸·¿°ÀÇ ºÐÆ÷ÀÔ´Ï´Ù. ¿¹¸¦ µé¾î¼­ 500 Á¤µµ¸é ¾à 25%´Â °áÇÙ¼º º¹¸·¿°À̾ú½À´Ï´Ù.


Á¶Á÷À¸·Î È®ÀÎµÈ ÀüÇüÀûÀÎ °áÇÙ¼º º¹¸·¿°ÀÇ Áõ·ÊÀÔ´Ï´Ù. Fig. 5. A case of tuberculous peritonitis. (A) A 68-year old woman came to the hospital with abdominal distention which developed 2 months prior. CT scan was taken and the first impression was peritoneal carcinomatosis. (B) Laparoscopy was done and the histology showed chronic granulomatous inflammation with multinucleated giant cells. (C) No ascites were seen at the follow-up CT scan, 4 months after taking anti-Mycobacterium medication.


°áÇÙ¼º º¹¸·¿°°ú ³­¼Ò¾ÏÀÇ ºñ±³ÀÔ´Ï´Ù.


°ü·Ã ¹®Çå 1: Etiologic and laboratory analyses of ascites in patients who underwent diagnostic paracentesis

°ü·Ã ¹®Çå 2: Clinical significance of serum CA 125 in patients with chronic liver diseases

°ü·Ã ¹®Çå 3: Differentiation of tuberculous peritonitis from peritonitis carcinomatosa without surgical intervention - Turkey ÀÇ»çµéÀÌ Saudi ArabiaÀÇ Àú³Î¿¡ ½ÇÀº ³»¿ëÀε¥ ¸Å¿ì clearÇÑ °á·ÐÀÔ´Ï´Ù. ÃÊ·Ï ÀϺθ¦ ¿Å±é´Ï´Ù.

In univariate analysis; fever, night sweats, and abdominal pain were significantly more frequent in the TBP group compared to those in the Ov Ca group (P < 0.001, P < 0.001, and P = 0.035, respectively) and the Ga Ca group (P < 0.001, P < 0.001, and P = 0.015, respectively). Serum CA 19-9 and carcino embryonic antigen (CEA) levels were significantly lower in the TBP and Ov Ca group compared to the Ga Ca group (P < 0.001 and P < 0.001, respectively). Elevated serum CA 125 level was found in all patients with TBP and Ov Ca and in 86.6% of patients with Ga Ca. In the multivariate analysis, presence of fever (P < 0.001), night sweats (P < 0.001), age under 40 years (P = 0.008), and normal serum CA 19-9 level (P = 0.044) were independent predictor of diagnosis of tuberculous peritonitis.


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