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[Opinion difference between Korea and Japan on gastric adenoma]

°Ç±¹´ëÇб³ À̼±¿µ ¼±»ý´Ô²²¼­ °æÈñ´ë¿¡¼­ ¹ßÇ¥ÇÑ ³í¹® Is Lesion Size an Independent Indication for Endoscopic Resection of Biopsy-Proven Low-Grade Gastric Dysplasia?(¿ø¹®¸µÅ©)¿¡ ´ëÇÑ editorialÀ» ¾´ °ÍÀÌ Àú³Î ȨÆäÀÌÁö Latest Articles¿¡ ¿Ã¶ó¿Ô½À´Ï´Ù.


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°æÈñ´ë ³í¹®¿¡¼­´Â Àúµµ¼±Á¾µµ ³»½Ã°æÀýÁ¦¸¦ ÇØ º¸¸é °íµµ¼±Á¾À̳ª ¾ÏÀ¸·Î ³ª¿À´Â °æ¿ì°¡ ÀûÁö¾ÊÀ½À» º¸¿©ÁÖ°í ÀÖ½À´Ï´Ù. ÇÙ½É figure¿Í °á·ÐÀº ¾Æ·¡¿Í °°½À´Ï´Ù.

Our data suggest that a substantial number of LGD diagnoses based on EFB were not representative of the entire lesion. We recommend ER if gastric LGD has at least one of the following risk factors: surface erythema and a depressed type regardless of size, or ¡Ã2 cm size regardless of abnormal surface configuration.

À̼±¿µ ¼±»ý´Ô²²¼­´Â Àúµµ¼±Á¾¿¡ ´ëÇÏ¿© ¾Æ·¡¿Í °°Àº ±×¸²À» º¸¿©Áָ鼭 Áß¿äÇÑ ¾ð±ÞÀ» ÇÏ°í ÀÖ½À´Ï´Ù.

The second concern relates to category 4 Vienna classifications for gastrointestinal epithelial neoplasia: 4.1 is HGD, 4.2 is noninvasive carcinoma in situ, and 4.3 is suspicious for invasive carcinoma with intramucosal carcinoma. Dysplasia is a precancerous lesion associated with a carcinoma risk increasing in parallel with the histological grade. Most Western pathologists use the term ¡°dysplasia¡± to describe a neoplastic premalignant abnormality; evidence of invasion into the lamina propria is needed to diagnose cancer. Nonetheless, while most Western pathologists require a structurally invasive focus for a cancer diagnosis, in the Japanese classification, there is no formal adenocarcinoma in situ classification. The fundamental concepts for the diagnosis of cancer are completely different between WHO classification and Japanese classification. Japanese pathologists diagnose cancer based on severe cytologic dysplasia, irrespective of the presence of invasion. Therefore, a considerable number of non-invasive intramucosal (intraepithelial) gastric neoplasms, so-called HGD outside Japan, are resected by ESD after being diagnosed as EGC in Japan. Although the Vienna classification was designed to reduce diagnostic discrepancies with Japan, it has been difficult to adopt due to differing criteria used to diagnose gastric epithelial neoplastic lesions . Thus, the prevalence of EGC is inflated in Japan since lesions that most Western pathologists identify as HGD are often considered intramucosal adenocarcinomas in Japan.

²À Àо¾Æ¾ß ÇÒ Áß¿äÇÑ editorialÀ̶ó°í »ý°¢ÇÕ´Ï´Ù. Àϵ¶À» °­ÃßÇÕ´Ï´Ù (PDF).


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