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[Barrett esophagus]

2013³â 9¿ù 16ÀÏ EndoTODAY¿¡ ¾Æ·¡¿Í °°Àº Áú¹®À» º¸³Â½À´Ï´Ù. ¸î ºÐ ¼±»ý´Ô²²¼­ ÁÁÀº ÀÇ°ßÀ» Áּ̽À´Ï´Ù. ¼Ò°³ÇÕ´Ï´Ù.

[¹®Á¦] ´ëÇÑÀ§Àå³»½Ã°æÇÐȸ¿¡¼­´Â Çмú´ëȸ¸¶´Ù quiz¸¦ ³»°í ÀÖ½À´Ï´Ù. ¸Å¿ì ÈǸ¢ÇÑ ÀüÅëÀ̶ó°í »ý°¢ÇÕ´Ï´Ù. À̹ø¿¡´Â ¹Ù·¿ ½Äµµ¿¡ ´ëÇÑ ¹®Á¦°¡ ÀÖ¾ú½À´Ï´Ù. ¿©·¯ºÐÀº ¾î¶»°Ô »ý°¢ÇϽʴϱî? 1, 2, 3, 4¹ø »çÁø¿¡ ´ëÇÑ ÀڽŸ¸ÀÇ ¼³¸íÀ» Á¦°Ô º¸³»ÁÖ½Ã¸é °¨»çÇÏ°Ú½À´Ï´Ù.

¾Öµ¶ÀÚ1¹ø2¹ø3¹ø4¹ø
¾Öµ¶ÀÚ N1 short segment Barrett esophagus --> palisade zoneÀÌ ¾ø¾îÁö´Â EGJº¸´Ù SCJÀÌ Á¶±Ý À§·Î ¿Ã¶ó°¡ ÀÖ½À´Ï´Ù.Barrett adenocarcinoma°¡ ÀÇ½ÉµÊ --> palisade zone¿¡ columnar epitheliumÀÌ º¸ÀÌ´Â ÀÌÀ¯·Î Barrett esophagusÀÌ°í 3½Ã¹æÇâ¿¡¼± squamous island°¡ ÀÖ°í protruding type Barrett adenocarcinoma°¡ ÀǽɵÊ.Hiatal hernia¿Í µ¿¹ÝµÈ Barrett esophagus --> 3¹øÀº EGJ¸¦ È®ÀÎÇϱ⠾î·Æ°í palisade zoneµµ Àß ¸ð¸¦°Ú½À´Ï´Ù. ±×·¯³ª ±í¼÷È÷ ¾Æ·¡¿¡ EGJ°¡ ÀÖ´Â °Í °°°í SCJ°¡ »ó´çÈ÷ ¿Ã¶ó¿Í À־ Barrett esophgus·Î º¸ÀÔ´Ï´Ù.Non-erosive reflux disease¿Í µ¿¹ÝµÈ Barrett esophagus --> À§ÁÖ¸§ÀÇ ±ÙÀ§ºÎ¸¦ EGJ¶ó ÇÒ¶§ SCJ°¡ ÀÌÀÇ »ó¹æ¿¡ À־ Barrett esophgus·Î º¸ÀÔ´Ï´Ù. mucosal break°¡ ¾ø°í Z-line blurring°ú white turbid discolorationÀ¸·Î º¸¿©¼­ Non-erosive reflux disease°¡ µ¿¹ÝµÇ¾î ÀÖ´Â °ÍÀ¸·Î º¸ÀÔ´Ï´Ù.
¾Öµ¶ÀÚ K¹Ù·¿ ½Äµµ°¡ ¸Â´Â °Í °°½À´Ï´Ù. most proximal part of gastric folds ·Î Á¤ÀǵǴ EG junction°ú squamocolumnar junction ÀÌ ÀÏÄ¡ÇÏÁö ¾Ê´Â °Í °°½À´Ï´Ù.¹Ù·¿½Äµµ´Â ¾Æ´Ñ °Í °°½À´Ï´Ù. mucosal break ÀÌ º¸ÀÌ°í reflux esophagitis ¼Ò°ßÀº º¸ÀÌ´Â °Í °°½À´Ï´Ù.Hiatal hernia ¿Í µ¿¹ÝµÈ Barrett esophagus ÀÎ °Í °°½À´Ï´Ù.Á» ¾Ö¸ÅÇÕ´Ï´Ù. À§Á¡¸·ÁÖ¸§ ³¡(EG junction) ÀÌ º¸ÀÌ°í ¾à°£ ¶³¾îÁ®¼­ squamocolumnar junction ÀÌ À§Ä¡ÇØ ÀÖ´Â short segment ¹Ù·¿ ½Äµµ°¡ ¾Æ´Ò±î ÇÕ´Ï´Ù.
¾Öµ¶ÀÚ N2GEJ°ú PZÀÇ ±¸ºÐÀÌ ¸íÈ®ÇÏ°í ±× À§·Î ¼±È«»öÀ¸·Î º¯»öµÈ »óÇÇ(SCJ)¿Í »óÇÇÇÏ Ç÷°üÀÌ °üÂûµË´Ï´Ù. ¸Å¿ì ÀüÇüÀûÀÎ short segment BE·Î »ý°¢µË´Ï´Ù.RE°¡ °üÂûµË´Ï´Ù. ±×¸®°í ¼Õ¶ó¶ô ¸ð¾çÀ¸·Î µ¹ÃâµÈ ¼±È«»öÀÇ º¯»öµÈ »óÇÇ¿Í »óÇÇÇÏ Ç÷°üÀÌ °üÂûµË´Ï´Ù. RE¿Í µ¿¹ÝµÈ short segment BE·Î »ý°¢ÇÕ´Ï´Ù.¾Æ¿ï·¯, mucosal break Á÷ÇϹ濡 À¶±âµÈ ºÎºÐÀÌ °üÂûµÇ´Âµ¥, sentinel polypÀÎÁö BE adenoca. ÀÎÁö ¾Æ´Ï¸é gastric cancer ÀÎÁö´Â Á¶Á÷°Ë»ç¸¦ ÅëÇÑ È®ÀÎÀÌ ÇÊ¿äÇÒ °Í °°½À´Ï´Ù.GEJÀÇ ±¸ºÐÀÌ ¸íÈ®ÇÏÁö ¾Ê´Â hiatal hernia°¡ µ¿¹ÝµÇ¾î ÀÖ½À´Ï´Ù. PZ¿¡ »óÇÇÇÏ Ç÷°üÀÌ °üÂûµÇ´Â BE°¡ Àǽɵ˴ϴÙ.GEJº¸´Ù »ó¹æÀ¸·Î ¸Å¿ì ªÀº ´ÜºÐÀýÀÇ ¼±È«»öÀ¸·Î º¯»öµÈ Á¡¸·ÀÌ °üÂûµÇ¸ç, ÀϺΠ»óÇÇÇÏ Ç÷°üÀÌ °üÂûµË´Ï´Ù. Ultra-short segment BE·Î »ý°¢µÇ¸ç ÀÓ»óÀû Àǹ̴ ¾øÀ»°Í °°½À´Ï´Ù.
¾Öµ¶ÀÚ J½Äµµ¿¡ ¿°Áõ¼Ò°ßÀº °üÂûµÇÁö ¾ÊÀ¸³ª short setment BarrettÀÌ °üÂûµË´Ï´Ù,Reflux esophagitis LA-B, sentinel polyplong segment Barretthiatsl hernia´Â ±âº»ÀûÀ¸·Î °üÂûÀÌ µÇ°í GE junction°ú SC junctionÀ» ¾à°£ óÀÌ°¡ ³ª°Ô º»´Ù¸é ultrashort segment BarrettÀÌ ÀÖ´Ù°í º¼ ¼öµµ ÀÖ°í, hiatal hernia¸¸ ÀÖ´Ù°í º¼ ¼öµµ ÀÖ°Ú½À´Ï´Ù.
¾Öµ¶ÀÚCLErefulx ¸¸Long BE¾Ö¸ÅÇÏÁö¸¸ G-fold ±âÁØÀ¸·Î 9½Ã-12½Ã´Â Short BE
¾Öµ¶ÀÚ YSSBEesophagocolumnar jx ÀÌ ºÒÈ®½ÇÇØ Àß ¸ð¸£°Ú½À´Ï´Ù.tongue like projectionÀ» °®´Â long seg ÀÇ BEHiatal hernia
¾Öµ¶ÀÚ SEGjº¸´Ù ÆíÆò-¿øÁÖ»óÇÇÁ¢Çպΰ¡ »ó¹æÀ¸·Î ¿Ã¶ó°¡°í 9½Ã¹æÇâ¿¡ »óÇÇÇÏ Ç÷°ü¼Ò°ßÀ¸·Î ¹Ù·¿½Äµµ ÀÇ½É ¼Ò°ß2½Ã ¹æÇâ¿¡ ÃâÇ÷°æÇâÀ» º¸ÀÌ´Â À¶±âº´º¯ÀÌ ÀÖ´Â ´ÜºÐÀý ¹Ù·¿½Äµµ ¼Ò°ß.ÆíÆò»óÇÇ°¡ ¿øÁÖ»óÇÇ·Î ¹Ù²î¸ç »ý±ä 7½Ã ¹æÇâÀÇ ÆíÆò»óÇÇ»ù ¼Ò°ßÀÇ ÀåºÐÀý ¹Ù·¿½Äµµ ¼Ò°ß.9~10¹æÇâ º¸ÃÊÆú¸³ ¼Ò°ß°ú Á¡¸·¼Õ»ó°ú ¹é»öȥŹÀ» µ¿¹ÝÇÑ ¿ª·ù¼º½Äµµ¿° ¼Ò°ßÀ¸·Î
¾Öµ¶ÀÚ PÀ§-½Äµµ »óÇÇ Á¢Çպΰ¡ ½Äµµ Á¡¸·ÇÏ ¹Ì¼¼ Á¾ÁÖÇ÷°üÀÌ Á¸ÀçÇÏ´Â ½Äµµ ºÎÀ§¸¦ Áö³ª »ó¹æÀ¸·Î À̵¿ÇØ ÀÖ¾î ¹Ù·¿½Äµµ¿¡ ÇØ´çÇÏ´Â °ÍÀ¸·Î º¸ÀÔ´Ï´Ù.(±æÀÌ°¡ 1-2cm Á¤µµ·Î short segment Barrett's esophagus)¹Ù·¿½Äµµ¶ó ÇÒ¸¸ÇÑ ºÎÀ§´Â º¸ÀÌÁö ¾ÊÀ¸¸ç ÇϺνĵµ°¡ ÀüüÀûÀ¸·Î ¹ßÀûµÇ¾î º¸ÀÌ¸ç µÎ½Ã ¹æÇâ¿¡ º¸ÀÌ´Â ¼±Çü º´º¯ÀÌ ¹«¾ùÀÎÁö Çò°¥¸®´Âµ¥ sentinnel polyp À§ÂÊÀ¸·Î mucosal break³ª ulcer°¡ healedµÈ ¸ð½À°°±âµµ ÇÏ°í Àß ±¸º°ÀÌ ¾ÈµË´Ï´Ù.ÀüÇüÀûÀÎ long segment Barrett's esophagus·Î º¸À̴µ¥ ¿°Áõ¶§¹®ÀÎÁö È­¸é ¶§¹®ÀÎÁö Á¾ÁÖÇ÷°üÀº Àß °üÂûµÇÁö ¾Ê´Â °Í °°½À´Ï´Ù.Gastric folds°¡ Ⱦ°æ¸·ÀÇ esophageal hiatus À§ÂÊÀ¸·Î À̵¿ÇÑ hiatal hernia ¼Ò°ßÀ¸·Î º¸ÀÔ´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 1] Àú´Â Barrett's esophagus´Â 1,3¹ø °°½À´Ï´Ù. 2¹øÀÇ °æ¿ì´Â GERDÀÇ mucosal breakÀÇ º¯Çü (¹é»öÁ¶ º¯È­?)·Î º¸ÀÌ°í, 4¹øÀÇ °æ¿ì´Â ÁÖ¸§ÀÌ ¸¹ÀÌ Á®¼­ eosinophilic esophagitis¸¦ °¨º°Çغ¼ °Í °°½À´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 2] ÀÏ°ß º¸±â¿¡ 2, 3, 4´Â hiatal hernia ¸¦ µ¿¹ÝÇÑ ¿ª·ù¼º ½Äµµ¿° ¼Ò°ßÀÔ´Ï´Ù. Àß ¾Èº¸À̳ª 1¹øÀº 9½Ã ¹æÇâÀÌ short segment ¹Ù·¿À¸·Î Àǽɰ¡´É. 4¹ø »çÁøÀº Àß ¾Èº¸ÀÓ. Çã´Ï¾Æ°¡ ´Ù¼Ò ½ÉÇÑ µí.


[¾Öµ¶ÀÚ ´äº¯ 3] Ç×»ó ÁÁÀº ³»¿ëµé°ú »õ·Î¿î update, ±×¸®°í ÀÇ»çµé °£ ¿Â¶óÀÎ Ä¿¹Â´ÏÄÉÀÌ¼Ç °ø°£ ¸¶·ÃÀ̶ó´Â ÀåÀ» ¸¶·ÃÇØ Áּż­ °¨»çµå¸³´Ï´Ù. º´¿ø¿¡ ÀÖ¾î¾ßÁö ²À °øºÎ¸¦ ÇÏ´Â °ÍÀÌ ¾Æ´Ï¶ó, °­È£¿¡ ÀÖÀ¸¸é¼­µµ ÀÌ·¯ÇÑ ÀÚ·áµéÀ» Á¢Çϸ鼭 '¾ÆÇÏ~, ±×·¨¾ú±¸³ª'¶ó´Â °¨Åº»ç°¡ ³ª¿Ã¶§ ¸¶´Ù »õ»ï °øºÎ¶õ °ÍÀº ²÷ÀÓ¾øÀÌ ÇØ¾ß µÈ´Ù´Â °ÍÀ» ´À²¼½À´Ï´Ù.

Quiz¿¡ ´ëÇÑ ÀúÀÇ °£´ÜÇÑ ¼³¸íÀ» µå¸®ÀÚ¸é

1) 3) EGJ º¸´Ù squamo-columnar epitheliumÀÌ »ó¹æÀ¸·Î À̵¿ÇÏ¿© ¹Ù·¿ ½Äµµ¸¦ ÀǽÉÇÒ ¼ö ÀÖ°Ú½À´Ï´Ù. ´Ù¸¸ 1)ÀÇ °æ¿ì´Â 3cm ¹Ì¸¸ÀÇ ´ÜºÐÀý ¹Ù·¿, 3)ÀÇ °æ¿ì´Â ±æÀÌ°¡ Á» ´õ ±æ¾î(EGJ¿¡¼­ 3cm ÀÌ»ó µÇ¾î º¸À̳׿ä) ÀåºÐÀý ¹Ù·¿À¸·Î º¸ÀÔ´Ï´Ù.

2) ÀÏ°ß 5mm ÀÌ»óÀÇ ¼±»ó ¹Ì¶õÀÌ µ¿¹ÝµÇ¾î ÀÖ¾î RE(B)·Î º¸À̳׿ä.

4) Proximal margin of gastric fold°¡ º¸ÀÌ°í, ±×·¸±â¿¡ ¹Ù·¿ÀÌ ¾Æ´Ï¶ó hiatal hernia°¡ ¾Æ´Ò±î ½Í½À´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 4]

1,3) Barrett's esophagus : tubular mucosal extension from Z-line.

2) Reflux esophagitis, LA grade B : linear mucosal breaks, more than 5 mm

4) Reflux esophagitis, LA grade M : ectopic gastric mucosal islets / blurring and coarseness of Z line


[¾Öµ¶ÀÚ ´äº¯ 5] Àú´Â 1¹øÀº SSBE, 2¹øÀº RE, LA-B, 3¹øÀº BE, 4¹øÀº RE, minimal changeÀ¸·Î »ý°¢ÇÏ¿´½À´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 6]

1¹ø, 3¹ø: EG junction º¸´Ù ¿øÁÖ»óÇÇ°¡ »ó¹æÀ¸·Î ´õ ¸¹ÀÌ ¿Ã¶ó¿Í ÀÖ½À´Ï´Ù. (¹Ù·¿½Äµµ)

2¹ø: EG junction »ó¹æÀ¸·Î linear mucosal break ¼Ò°ß °üÂûµË´Ï´Ù.

4¹ø: »çÁø¿¡¼­ °æ°èºÎÀ§°¡ ¶Ñ·ÇÇÏ°Ô º¸ÀÌÁö ¾Ê½À´Ï´Ù. EG junction°ú ÆíÆò-¿øÁÖ»óÇÇ °æ°è°¡ ÀÏÄ¡ÇØ º¸ÀÔ´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 7] ¹Ù·¿½Äµµ´Â ºÁµµ ºÁµµ ¿ØÁö ÀÚ½ÅÀÌ ¾ø½À´Ï´Ù ¤Ð¤Ð

¸ðµÎ ¹Ù·¿½Äµµ ÀÎ°Í °°Àºµ¥¿ä... 3¹øÀº ÆíÆò»óÇǼ¶ÀÌ º¸ÀÌ´Â ÀåºÐÀý ¹Ù·¿½Äµµ, ³ª¸ÓÁö´Â ¸ðµÎ ´ÜºÐÀý ¹Ù·¿½Äµµ ÀÎ °Í °°½À´Ï´Ù. 4¹ø °°Àº °æ¿ì´Â ¿øÁÖ»óÇǼ¶ÀÌ º¸ÀÌ´Â ¹Ù·¿½Äµµ, focal ÇÏ°Ô ¹Ù·¿±â¿ø ½Äµµ¼±¾ÏÀ» ÀǽÉÇÒ ¸¸ÇÑ ¼Ò°ßµµ º¸ÀÌ´Â°Í °°±¸¿ä.


[¾Öµ¶ÀÚ ´äº¯ 8]

1 short segment CLE

2 RE LA B suspected sentinel polyp

3 long segment CLE

4 hiatal hernia

»ó±â º´º¯¿¡¼­ ½ÇÁ¦ Á¶Á÷°Ë»ç°á°ú BE(specialized intestinal metaplasia)·Î Áõ¸íµÉ °¡´É¼ºÀº 3¹øÀÌ Á¦ÀÏ ³ô°í ±×´ÙÀ½ÀÌ 1¹ø.

Áú¹®: 1À̳ª 3¹øÀÇ °æ¿ì ³»½Ã°æÁø´ÜÀº CLE·Î ±â¼úÇϽôÂÁö¿ä ¾Æ´Ï¸é BE·Î ?


[¾Öµ¶ÀÚ ´äº¯ 9] ´äÀº ³ª,¶ó °°½À´Ï´Ù. 2)Àº sentinel polypÀÌ µ¿¹ÝµÈ °Í °°°í 4)´Â island°¡ ÀÖ´Â °Í °°½À´Ï´Ù. 1)Àº hiatal herniaÀÎ °Í °°°í 3)Àº RE °°½À´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 10] 1,3,4 ¹ø °°½À´Ï´Ù. 2¹øÀº ºÓ°Ô ÂïÈù °ÍÀÎÁö, ¹ßÀûÀÎÁö Àß ¸ð¸£°ÚÀ¸³ª Á¾ÁÖÇ÷°üµµ Àß º¸ÀÌ°í ½Äµµ Á¡¸·°°½À´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 11] ¼÷Á¦¸¦ Áּż­ ÁÖ¸»¿¡ ´äÇÕ´Ï´Ù. Á¶Á÷°Ë»ç·Î SIMÀ» ¾òÀº °æ¿ì´Â ¾ø½À´Ï´Ù¸¸, ¾î·Á¿î °Í°°½À´Ï´Ù. °æºñ³»½Ã°æÀ¸·Î °üÂûÀº ÆíÇÏÁö¸¸, Palisade zoneÀÇ Ç÷°ü»ó°ú ¿øÁÖ»óÇǺκÐÀ» ±¸ºÐÇϱâ´Â ºÒÆíÇÕ´Ï´Ù. °üÂûÀÚÀÇ Â÷ÀÌ¿Í ³»½Ã°æ ÀåºñÀÇ Â÷À̵µ °í·ÁÇØ¾ß ÇÒ °Í °°½À´Ï´Ù. Àú´Â 1,2,3ÀÇ ³»½Ã°æ¼Ò°ß¿¡ Barrett's esophagus ÀǽÉÀ» ÇÕ´Ï´Ù.


[¾Öµ¶ÀÚ ´äº¯ 12] 1,3¹øÀº ¹Ù·¿½Äµµ. 2¹øÀº adenoma ÀǽÉ, 4¹øÀº È£ÈíÁ¶ÀýÀÌ ¾È µÈ »óÅ¿¡¼­ ÂïÀº»çÁøÀ¸·Î ±¸ºÐÀÌ ¾È µÊ


ÀÇ°ßÀ» ÁֽŠ¾Öµ¶ÀڴԵ鲲 °¨»çµå¸³´Ï´Ù. ÀúÀÇ ÀÇ°ßÀº ¾Æ·¡¿Í °°½À´Ï´Ù.

1¹ø: r/o Short segment Barrett esophagus¶ó°í ¾²°í Á¶Á÷°Ë»ç¸¦ 2Á¡ ÇÒ °Í °°½À´Ï´Ù.

2¹ø: Reflux esophagitis, LA-B¶ó°í ¾²°í Á¶Á÷°Ë»ç´Â ¾È ÇÒ °Í °°½À´Ï´Ù. ¹Ù·¿Àº ¾ð±ÞÇÏÁö ¾Ê°Ú½À´Ï´Ù.

3¹ø: Barrett esophagus¶ó°í ¾²°í 2°÷ Á¤µµ¿¡¼­ Á¶Á÷°Ë»ç¸¦ ÇÏ°Ú½À´Ï´Ù. ³Ê¹« ÀüÇüÀûÀÎ ¼Ò°ßÀ̹ǷΠr/o Barrett esophagusó·³ ¾²Áö ¾ÊÀ½¿¡ À¯ÀÇÇØ Áֽñ⠹ٶø´Ï´Ù.

4¹ø: Sliding type hiatal hernia·Î ¾²°Ú½À´Ï´Ù. Á¶Á÷°Ë»ç´Â ÇÊ¿äÇÏÁö ¾Ê½À´Ï´Ù.

º¸´Ù ÀÚ¼¼ÇÑ ¼³¸íÀº 2013³â 10¿ù 19ÀÏ EndoTODAY¸¦ Âü°íÇϱ⠹ٶø´Ï´Ù.


[2013-10-2. LA Times] Unnecessary mastectomies: Patients more fearful than they need to be

[2013-10-2. ÇÁ·¹½Ã¾È] °Ü¿ï µî»ê ÁغñÇϴ٠ȣÈí °ï¶õ¡¦»ç¶÷ Àâ´Â '¹æ¼öÁ¦'


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