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[Final posting of EndoTODAY Weekly - The initial biopsy of an AGC may be high grade dysplasia]

A patient was referred with a biopsy result of adenoma with high grade dysplasia.

The lesion was located at the lesser curvature side of the distal antrum. The antrum was not fully expanded, so I decided to repeat the endoscopy. An ulcerative area was found in the repeat endoscopy, and malignancy was confirmed in the biopsy. Surgery was done, and the final pathological staging was T3N1.

Advanced gastric carcinoma
1. Location : lower third, center at antrum and lesser curvature
2. Gross type : Borrmann type 3
3. Histologic type : tubular adenocarcinoma, moderately differentiated
4. Histologic type by Lauren : intestinal
5. Size : 2.7x2 cm
6. Depth of invasion : penetrates subserosal connective tissue (pT3)
7. Resection margin: free from carcinoma, safety margin: proximal 4 cm, distal 1 cm
8. Lymph node metastasis : metastasis to 2 out of 50 regional lymph nodes (pN1), perinodal extension: absent, (2/50: "1", 0/0; "3", 0/9; "4", 0/17; "4sb", 0/1; "5", 0/1; "6", 1/7; "8a", 0/4; "7", 1/4; "9", 0/5; "11p", 0/1; "12a", 0/1)
9. Lymphatic invasion : present
10. Venous invasion : not identified
11. Perineural invasion : not identified
12. Peritoneal cytology : negative
13. AJCC stage by 7th edition: pT3, N1


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