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[Korea-US collaborative healthcare forum - Gastric cancer disparity]

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Joo Ha Hwang (Stanford U)

Stomach cancer is the 3rd leading cause of cancer death worldwide.

¹Ì±¹¿¡¼­ À§¾Ï ¹ß»ý·üÀº 15À§ (27,510¸í)Àε¥, 16À§ÀÎ ½Äµµ¾Ï(17,650¸í)º¸´Ù ÈçÇÔ¿¡µµ ºÒ±¸ÇÏ°í ½Äµµ¾Ï¿¡ ºñÇÏ¿© ÁÖ¸ñ¹ÞÁö ¸øÇÏ°í ÀÖ½À´Ï´Ù. À§¾ÏÀº Asian American¿¡ ¸¹°í, ½Äµµ¾ÏÀº Barrett À̶ó´Â ¶Ñ·ÇÇÑ precursor lesionÀÌ Àֱ⠶§¹®¿¡ º¸´Ù ¸¹Àº °ü½ÉÀ» ¹Þ´Â °Í °°½À´Ï´Ù. Intestinal metaplasia°¡ ÀÖÀ» ¶§ À§¾Ï ¹ß»ý À§Çè·ü(OR)Àº 9.3, East AsianÀº 15.9À̸ç (Choi AY, Strate LL, et al - in press), intestinal metaplasia°¡ caucasian¿¡¼­µµ ¹ß°ßµÊ¿¡µµ ºÒ±¸ÇÏ°í...

Paul Choi (LA Endoscopy Center)

1930³â¿¡´Â ¹Ì±¹¿¡¼­µµ À§¾ÏÀÌ °¡Àå ÈçÇÑ ¾ÏÀ̾ú½À´Ï´Ù. 2010³â¿¡´Â 1930³â¿¡ ºñÇÏ¿© 90% ÀÌ»ó °¨¼ÒÇÏ¿´½À´Ï´Ù. 100 consecutive EGD Áõ·Ê¸¦ ºÐ¼®ÇÏ¿´À» ¶§ pure screening ¸ñÀûÀº 2¸íÀ̾ú½À´Ï´Ù.

»ý°¢º¸´Ù ¸¹Àº ¾ÏÀÌ ¹ß°ßµÇ¾ú½À´Ï´Ù. 100¸í Áß 5¸í

Kim Hei Ryu (±¹¸³¾Ï¼¾ÅÍ, ÀÏ»ê)

Young-Woo Kim (±¹¸³¾Ï¼¾ÅÍ, ÀÏ»ê)

Çѱ¹¿¡¼­ non-compliance ¹®Á¦´Â ¾ÆÁ÷µµ ½É°¢ÇÕ´Ï´Ù.

À§¾Ï ¼ö¼úÀÌ ¸Å¿ì centralized µÇ¾î ÀÖ½À´Ï´Ù.

"Open surgery is not standard."¶ó°í °­Á¶Çϼ̽À´Ï´Ù. Less invasive surgeryÀÇ ½Ã´ëÀÔ´Ï´Ù.

Yanghee Woo (City of Hope hospital)

Áß±¹ ´ÙÀ½À¸·Î ¸¹Àº Çѱ¹ÀÎÀÌ ¹Ì±¹¿¡¼­ »ì°í ÀÖ½À´Ï´Ù. °ÅÀÇ 200¹é¸¸¸íÀÔ´Ï´Ù. ±× Áß 35¸¸¸í ÀÌ»óÀÌ LA¿¡ »ì°í ÀÖ½À´Ï´Ù.

Korean AmericanÀÇ À§¾Ï ¹®Á¦´Â Korea-US collaborationÀ¸·Î Ç® ¼ö ÀÖ´Ù´Â ÁÖÀåÀÌ ÀλóÀûÀ̾ú½À´Ï´Ù.

ÀÌÁØÇà (¼º±Õ°üÀÇ´ë)

PPT PDF. °­ÀÇ ³»¿ëÀº ÀÌ¹Ì YouTube¿¡ ¿Ã·ÁµÎ¾ú½À´Ï´Ù.

¼ÕÅÂÀÏ (¿¬¼¼´ë)

¸Å³â 600°Ç ÀÌ»óÀÇ robotic gastrectomy°¡ ÁøÇàµÇ°í ÀÖ½À´Ï´Ù. Blood loss°¡ Àû°í hospital stay°¡ ª°í learning curve effect°¡ ÀûÀº ÀåÁ¡ÀÌ ÀÖÀ¸¸ç, longterm oncologic outcome¿¡ ´ëÇÑ µ¥ÀÌŸ°¡ ´õ ÇÊ¿äÇÑ »óÅÂÀÔ´Ï´Ù.

Reduced port robotic gastrectomy (3 port)°¡ standard 5 port laparoscopic surgery¿¡ ºñÇÏ¿© lymph node harvest°¡ ¸¹¾Ò´Ù°í ÇÕ´Ï´Ù.

±èÇüÀÏ (ºÐ´ç¼­¿ï´ë)

ÀϺ» °¡À̵å¶óÀÎÀº clinical stage I¿¡ ´ëÇؼ­¸¸ ¾ð±ÞÇÏ°í ÀÖÀ¸³ª ¿ì¸®³ª¶ó °¡À̵å¶óÀο¡¼­´Â EGC (strong recommendation, strong evidence) »Ó¸¸ ¾Æ´Ï¶ó AGC (moderate recommendation, weak evidence)¿¡¼­µµ laparoscopic surgery¸¦ ÃßõÇÏ°í ÀÖ½À´Ï´Ù.

KLASS-01 (Laparoscopic gastrectomy for EGC)
- Retrospective cohort: JCO 2014;32:627
- Shortterm outcome: Annals of Surgery
- Longterm outcome: JAMA Oncology 2019;5:506-513
[Results] Among the 1416 patients (mean [SD] age, 57.3 [11.1] years; 940 [66.4%] male) included in the study, the 5-year overall survival rates were 94.2% in the laparoscopic group and 93.3% in the open surgery group (log-rank P=.64). Intention-to-treat analysis confirmed the noninferiority of the laparoscopic approach compared with the open approach (difference, 0.9 percentage points; 1-sided 97.5% CI, -1.6 to infinity). The 5-year cancer-specific survival rates were similar between the 2 groups (97.1% in the laparoscopic group and 97.2% in the open surgery group, log-rank P=.91; difference, -0.03 percentage points; 1-sided 97.5% CI, -1.8 to infinity). Per-protocol analysis results were consistent with the intention-to-treat results for overall and cancer-specific survival rates.

KLASS-02 (Laparoscopic subtotal gastrectomy for AGC)
- Shortterm outcome: Ann Surg 2019;

KLASS-03 (Laparoscopic total gastrectomy for clinicl stage I)

ºÐ´ç¼­¿ï´ëº´¿øÀÇ À§¾Ï ¼ö¼ú »ç¸Á·üÀº ¸Å¿ì ³·¾Ò½À´Ï´Ù. Average mortality´Â 0.07%, Surgery related mortality´Â 0.03% (3/7655)¿´½À´Ï´Ù.

±èÅ¿ë (¼­¿ï´ë)

Samuel Klempner (Massachusetts General Hospital, Harvard Medical School)

¾àÁ¦ÀÇ È¿°ú¸¦ ¹Ý¿µÇÏ´Â progression free survivalÀº µ¿¼­°¡ ºñ½ÁÇѵ¥, ÀüüÀûÀÎ Ä¡·áÀÇ ÁúÀ» ¹Ý¿µÇÏ´Â overall survivalÀº ¾Æ½Ã¾Æ°¡ ¿ì¼öÇß½À´Ï´Ù. µ¿¾ç¿¡¼­ ¼­¾ç¿¡ ºñÇÏ¿© care¸¦ ´õ Àß ÇÏ°í ÀÖ´Ù´Â °ÍÀ» º¸¿©ÁÖ°í ÀÖ½À´Ï´Ù.

Yanghee Woo (City of Hope)

Korean AmericanÀÇ À§¾Ï ¹ß»ý·üÀº Korean in Koreaº¸´Ù´Â ³·°í Japanese Americanº¸´Ù´Â ³ô½À´Ï´Ù.

Joseph Chao


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© ÀÏ¿ø³»½Ã°æ±³½Ç ¹Ù¸¥³»½Ã°æ¿¬±¸¼Ò ÀÌÁØÇà. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng.