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[NK T-cell lymphoma] - ðû


1. NK T-cells

- NK cells are a subset of lymphocytes that mediate innate immunity and regulate adaptive immunity via cytokine secretion and cytokine activity.

- The activation of NK cell function is a result of the integration of activating and inhibitory signals delivered by NK cell receptors.

- Cells can become sensitive to NK cell-mediated cytotoxicity for various reasons, such as loss of MHC class I expression or upregulation of surface molecules in response to DNA damage or stress, which can occur as a result of infection or transformation.


2. Extranasal NK/T-cell lymphoma

- An Independent disease entity

- Poor survival outcome 5YSR = 37.9% ~ 45.3%


3. GI NK/T-cell lymphoma

- One of the most aggressive lymphomas

- Endoscopic evaluation: assessment of morphology and pathologic diagnosis

- Endoscopic findings in cases with primary NK/T-cell lymphoma of the GI tract?


4. Endoscopic findings of GI NK/T-cell lymphomas

»ï¼º¼­¿ïº´¿ø¿¡¼­ Áø´ÜÇÑ NK T-cell lymphoma »çÁøÀ» ¸ð¾Æ¼­ ¹ßÇ¥ÇÑ ¹Ù ÀÖ½À´Ï´Ù. »çÁøÀ» ¼Ò°³ÇÕ´Ï´Ù. »óºÎ 6 Áõ·Ê, ÇϺΠ5Áõ·Ê¿´½À´Ï´Ù.

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[Cases]


EXTRANODAL NK/T-CELL LYMPHOMA, nasal type
CD 3, T-CELL : Positive in tumor cells
Ki-67 : Positive in 60% of tumor cells
Cytokeratin (AE1/AE3) : Positive in disrupted gastric gland
CD 20, L26 : Negative in tumor cells
TIA-1, T cell : Focal positive in tumor cells
CD 30 : Negative in tumor cells
CD 56 : Negative in tumor cells
CD 8, (Leu-2a) : Negative in tumor cells
CD 4, (Leu-3a) : Positive in tumor cells
Epstein-Barr virus : Positive in tumor cells

ÀÌÈ­¿©ÀÚ´ëÇб³ Áõ·Êº¸°í

´ëÀå³»½Ã°æ. °í·É. üÁß°¨¼Ò¿Í Ç÷º¯. º´¸®: Extranodal NK/T cell lymphoma, nasal type, EBV (+)

© ÀÏ¿ø³»½Ã°æ±³½Ç ¹Ù¸¥³»½Ã°æ¿¬±¸¼Ò ÀÌÁØÇà. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng.