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[Upper GI involvement of Crohn's disease. Å©·Ðº´ ȯÀÚÀÇ »óºÎÀ§Àå°ü ³»½Ã°æ ¼Ò°ß]

1. Introduction ´ëÇѼÒÈ­±â³»½Ã°æÇÐȸ ±³À°ÀÚ·á, ±è±¤ÇÏ ±³¼ö´Ô Ã¥

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1. Introduction (Å©·Ðº´ÀÇ »óºÎÀ§Àå°ü ħ¹ü) - ´ëÇѼÒÈ­±â³»½Ã°æÇÐȸ ±³À°ÀÚ·á, ±è±¤ÇÏ ±³¼ö´Ô Ã¥

´ëÇѼÒÈ­±â³»½Ã°æÇÐȸ¿¡¼­ ÁÁÀº ±³À°ÀڷḦ º¸³»¿Ô½À´Ï´Ù.

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±è±¤ÇÏ ±³¼ö´Ô²²¼­ ¹ø¿ªÇϽŠ'»óºÎ¼ÒÈ­°ü ³»½Ã°æÁø´Ü ¾ÆƲ¶ó½º'¿¡µµ Èï¹Ì·Î¿î ³»¿ëÀÌ ÀÖ¾ú½À´Ï´Ù. ¿ÏÀüÈ÷ ÀϺ»½ÄÀ̳׿ä... Á¶±ÝÀº °úÀ×À¸·Î ´À²¸Áý´Ï´Ù. »ö¼Ò³»½Ã°æÀ̳ª Á¶Á÷°Ë»ç¸¦ ²À ÇØ¾ß ÇÏ´Â °ÍÀº ¾Æ´Õ´Ï´Ù.

º´¸®ÇÐÀûÀ¸·Î´Â focally enhanced gastritis°¡ Ư¡ÀûÀÔ´Ï´Ù.


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ÀÚ·áÁ¦°ø: °Ç±¹´ë À̼±¿µ ±³¼ö´Ô


3. Å©·Ðº´ ȯÀÚÀÇ À§ ¼Ò°ß

Intestinal Research 2016³â ùȣ¿¡ ½Ç¸° Gastric lesions in patients with Crohn¡¯s disease in Korea: a multicenter study¸¦ ¼Ò°³ÇÕ´Ï´Ù. Å©·Ð ȯÀÚ¿¡¼­ gastric noncaseating granuloma°¡ prognostic value¸¦ °¡Áú ¼ö ÀÖ´Ù´Â °á·ÐÀÌ ½Å¼±Çß½À´Ï´Ù.

Methods: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology. Results: There were 36 men (76.6%), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2-60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9%), and non-stricturing, nonpenetrating disease in 31 patients (66.0%). Twenty-eight patients (59.6%) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0%). Histopathologically, H. pylori-negative chronic active gastritis (38.3%) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4%), and gastric noncaseating granulomata were detected in 4 patients (8.5%). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/fistula (P=0.0496).

¼º±Õ°ü´ëÇб³ °­ºÏ»ï¼ºº´¿ø ¹Úµ¿ÀÏ ±³¼ö´ÔÆÀ¿¡¼­ Å©·Ðº´ ȯÀÚÀÇ À§³»½Ã°æ¿¡¼­ °üÂûµÇ´Â bamboo joint-like appearance¿¡ ´ëÇÑ ³í¹®À» ¹ßÇ¥ÇÑ ¹Ù ÀÖ½À´Ï´Ù (°­¹®¼ö. ´ëÇѼÒÈ­±â³»½Ã°æÇÐȸÁö 2006).

Typical gastroduodenal endoscopic findings in a Crohn's disease patient in remission stage (lizuka M. WGJ 2012)¶ó´Â Á¦¸ñÀÇ ÀϺ» ³í¹®¿¡µµ ÁÁÀº »çÁøÀÌ ÀÖ¾ú½À´Ï´Ù.

Gastroduodenal endoscopic findings of the patient. A: Endoscopic view of bamboo-joint-like appearance on the lesser curvature of the gastric body and cardia; B: Bamboo-joint-like appearance was more clearly observed by spraying with indigo carmine dye; C: Endoscopic view of notches on the Kerckring¡¯s folds of the duodenum; D: Notch sign was more clearly observed by spraying with indigo carmine dye; E: The bamboo-joint-like appearance was localized in the lesser curvature of the upper gastric body and cardia.

2021³â °Ç±¹´ë ³»½Ã°æ ÄûÁî Áß °ü·Ã Áõ·Ê°¡ ÀÖ¾ú½À´Ï´Ù.

Granulomatous gastritis in Crohn's disease

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Å©·Ðº´Àº º¸Åë ÇϺÎÀ§Àå°ü ÁúȯÀÌÁö¸¸ °£È¤ »óºÎÀ§Àå°ü ħ¹üÀ» º¸À̱⵵ ÇÕ´Ï´Ù. ¼ÒÀå¼ö¼úÀ» ÅëÇÏ¿© Å©·Ðº´À¸·Î È®ÁøµÈ ¹Ù ÀÖ´Â 50´ë ¿©¼ºÀ¸·Î duodenum¿¡¼­µµ Å©·Ðº´ÀÇ ÀüÇüÀûÀÎ longitudinal ulcer°¡ Àß º¸¿´´ø °æ¿ìÀÔ´Ï´Ù. ÀÌ Á¤µµ Ư¡ÀûÀ̸é Å©·Ðº´ÀÇ ½ÊÀÌÁöÀå ħ¹üÀ¸·Î Áø´ÜÇϴµ¥ ¹«¸®°¡ ¾ø´Ù°í »ý°¢µË´Ï´Ù. Å©·Ðº´ Ä¡·á¸¦ Çϸ鼭 È£ÀüµÈ Á¡µµ supporting evidenceÀÏ °ÍÀÔ´Ï´Ù. ±×·¯³ª °£È¤ ¾Ö¸ÅÇÑ ¼Ò°ß¸¸ º¸ÀΠȯÀÚ¿¡¼­´Â »óºÎÀ§Àå°ü Áúȯ°ú Å©·Ðº´°úÀÇ °ü·Ã¼ºÀ» ÀÔÁõÇϱ⠾î·Æ½À´Ï´Ù.


© ÀÏ¿ø³»½Ã°æ±³½Ç ¹Ù¸¥³»½Ã°æ¿¬±¸¼Ò ÀÌÁØÇà. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng.