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EndoTODAY 내시경 교실


[위장관 병리. Pathology of GI tract] - End of Document

1. Introduction

2. Selected lectures

3. Case studies - benign conditions of the GI tract

4. Case studies - malignant conditions of the GI tract

5. Others

6. FAQs

7. References


1. Introduction - Maryam Pezhouh


2. Selected lectures

Epithelial & Connective Tissues

Basics of tissues

Histology for beginners

Digestive histology

Logical Approach to the Luminal GI Biopsy

Gastric polyps - Mushrooms in the dirt (슬라이드를 너무 빨리 돌려서 정신이 하나도 없음)

조기위암 내시경 치료 후 병리학적 평가. 주미 (57회 내시경세미나)

  • When your GI biopsies are blue: a tour of GI lymphomas
  • Neuroendocrine Nuttiness in the Digestive System
  • Mesenchymal madness in the GI tract
  • Colonic polyps
  • The problematic colorectal polyp
  • Hyperplastic polyps not always what they seem (Mount Sanai Department of Pathology)

    Colitis: A pattern based approach

  • Adventures in the small intestine
  • Upper GI pathology for boards (난이도 上)

    Granuloma


  • 3. Case studies - benign conditions of the GI tract

    Chronic active gastritis

    H. pylori gastritis (Vikram Deshpande)

    Peptic ulcer

    Granulation tissue (organ: not clear)

    GAVE

    Traditional serrated adenoma


    4. Case studies - malignancy of the GI tract

    Esophageal cancer

    Barrett esophagus

    Cardia cancer (P/D) (WashingtonDeceit)

    Linitis plastica (WashingtonDeceit)

    제2회 내시경 병리 세미나 - AGC 혹은 EGC. SM3 massive에 대하여

    GIST of the stomach (전형적인 것 같지 않음)

    Crohn's disease

    정상 lymph node. 정상을 알아야 비정상도 알 수 있습니다.


    5. Others

    Mucin staining

    MUC2 Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5
    Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469)
    Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma
    Positive staining: intestinal and airway epithelium; mucinous carcinoma of colon, breast, pancreas, ovary and stomach
    Negative staining: stomach, breast ductal and lobular carcinomas
    MUC3 Upregulated by steroid hormones in vitro
    Positive staining: invasive breast carcinoma, gastric carcinoma (associated with poor prognosis)
    MUC4 Transmembrane or membrane bound mucin that provides a protective layer of mucus
    Normally acts as barrier to apical surface of epithelial cells, playing a protective and regulatory role
    Positive staining - normal: tracheobronchial mucosa, colon, stomach, cervix and lung; normal salivary glands
    Positive staining - disease: pancreatic, colonic, pulmonary and gastric carcinoma; sclerosing epithelioid fibrosarcoma (Am J Surg Pathol 2014;38:1538, Am J Surg Pathol 2012;36:1444)
    MUC5AC. Also known as MUC5 (GeneCards) Protects epithelium Positive staining - normal: stomach (foveolar epithelium of body and antrum), tracheobronchial mucosa, endometrium (mucinous metaplasia, eosinophilic change / metaplasia (Mod Pathol 2005;18:1243), surface syncytial change, ciliated change in 52%)
    Positive staining - disease: extramammary Paget disease but not mammary Paget disease or normal breast tissue (Am J Surg Pathol 2001;25:1469); mucinous carcinoma of ovary, diffuse type gastric carcinoma (83%)
    Negative staining: normal breast tissue
    MUC6 Produces protective glycoprotein coat for gut epithelia
    Positive staining - normal: stomach (pyloric glands), gallbladder, colon and endocervix
    Positive staining - disease: invasive ductal carcinoma of breast, gastric carcinomas
    Negative staining: normal breast tissue

    In a cohort of 97 gastric cancers 30% expressed MUC5AC and MUC6 (gastric phenotype), 40% expressed MUC5AC, MUC6 and MUC2 (gastrointestinal phenotype), 10% expressed MUC2 alone (intestinal phenotype) and 20% lacked all markers (null phenotype). (J Surg Oncol. 2008;98:124-129)

    - Pyloric type composed of columnar tumor cells : MUC6 positive
    - Foveolar type compoesed of tall tumor cells: MUC5AC positive

    Tuberculous lymphadenitis (참고: TB pathogenesis)

    Tuberculous lymphadenitis


    [FAQs]

    [2021-10-16] 병리 선생님. 제발 다른 sample은 따로따로 결과를 내 주세요. 하바터면 실수할 뻔 했습니다.

    첫 세 sample이 모두 암이었습니다. 세 개의 암이 있던 환자입니다. 그런데 병리 보고서는 실수하기 쉽게 씌여 있었습니다.


    [References]

    1) Pathologyonlines.com

    2) 알기 쉬운 병리학 PDF 13.5M

    3) Polypectomy/ESD Specimen 김경미 (2007년 내시경세미나) PDF 0.5M

    4) 위 조직 생검과 병리학적 진단 김용일 (제3회 내시경세미나)



    © 일원내시경교실 바른내시경연구소 이준행. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng