EndoTODAY | EndoATLAS | OPD

Parasite | Eso | Sto | Cancer | ESD

Boxim | DEX | Sono | Schedule

Home | Recent | Blog | Links

YouTube ¹Ù¸¥³»½Ã°æ¿¬±¸¼Ò


[StomachTODAY 043. Lanthanum deposition in the stomach]

Previous | Next

Åõ¼® ȯÀÚÀÇ ³»½Ã°æ Á¶Á÷°Ë»ç °á°ú°¡ "Some macrophage clusters with granular materials, suspected lanthanum (related with hemodialysis)"¿´½À´Ï´Ù.

È­Çпø¼Ò ¶õŸ³Ñ ¶Ç´Â ¶õź, ¶õŸ´½Àº ±âÈ£´Â La, ¿øÀÚ ¹øÈ£´Â 57ÀÔ´Ï´Ù. ¶õŸ³ÑÀº Àº¹é»öÀÇ ±Ý¼ÓÀ¸·Î ´ë°³ ¶õŸ³ÑÁ·À¸·Î ºÐ·ùÇϴµ¥ ¼¼·ýÀ̳ª ÈñÅä·ù ¿ø¼Ò¿Í ÇÔ²² »êÃâµË´Ï´Ù. ¶õŸ³ÑÀº °¡´Ü¼º°ú ¿¬¼ºÀÌ ÀÖ°í, Ä®·Î ÀÚ¸¦ ¼ö ÀÖÀ» ¸¸Å­ ¹«¸£°í ÈñÅä·ù ¿ø¼Ò Áß¿¡ °¡Àå ¹ÝÀÀ¼ºÀÌ Å©´Ù°í ÇÕ´Ï´Ù. Åõ¼®È¯ÀÚÀÇ Àå±â¿¡ ħÂøÇÒ¼ö ÀÖ½À´Ï´Ù. Àúµµ óÀ½ º¸´Â Çö»óÀ̹ǷΠÇÑ case seriesÀÇ ¼³¸íÀ» ¿Å±é´Ï´Ù (Intern Med. 2017).

Lanthanum carbonate, La2(CO3)3, has been widely used to treat hyperphosphatemia in patients with chronic kidney disease because this agent has a higher efficacy and tolerability compared to other conventional phosphate binders. After consuming lanthanum carbonate with meals, lanthanum binds with dietary phosphate. As a result, the formation of highly insoluble complexes, such as lanthanum phosphate, occurs, and prevents phosphate absorption via the intestine. The gastrointestinal tract minimally absorbs lanthanum phosphate complexes; therefore, most of the lanthanum phosphate is excreted via the feces. Despite its low bioavailability, accumulating evidence shows that lanthanum can be deposited in the gastrointestinal mucosa, particularly in the stomach. Endoscopic features included annular whitish mucosa (n = 4), diffuse whitish mucosa (n = 3), and whitish spots (n = 2).


[References]

1) EsoTODAY - ½ÊÀÌÁöÀåÁúȯ Áõ·ÊÅäÀÇ

2) SmallTODAY - ¼ÒÀåÁúȯ Áõ·ÊÅäÀÇ

3) ColonTODAY - ´ëÀåÁúȯ Áõ·ÊÅäÀÇ

4) Dr. Sinn's LiverTODAY - °£Áúȯ Áõ·ÊÅäÀÇ

© ÀÏ¿ø³»½Ã°æ±³½Ç ¹Ù¸¥³»½Ã°æ¿¬±¸¼Ò ÀÌÁØÇà. EndoTODAY Endoscopy Learning Center. Lee Jun Haeng (2020-6-19)