Mixed poorly differentiated neuroendocrine carcinoma and adenocarcinoma. EndoTODAY 이준행

[EsoTODAY 003 - Mixed poorly differentiated neuroendocrine carcinoma and adenocarcinoma]

Esophagus and upper stomach, Ivor Lewis operation :
Mixed poorly differentiated neuroendocrine carcinoma and adenocarcinoma, lower thoracic esophagus:
1) tumor size: 2x1.5 cm (neuroendocrine carcinoma 99%, adenocarcinoma 1%)
2) extension to submucosa
3) mitosis: 52/10 HPFs
4) necrosis: present
5) lymphovascular invasion: present
6) perineural invasion: not identified
7) resection margins: free from carcinoma, circumferential (adventitial) margin(deep), 0.4cm
8) metastasis to 7 out of 44 regional lymph nodes (7/44: "RRLN", 0/6; "LRLN", 0/6; "RD", 1/1; "G1", 2/6; "G2", 0/2; "G3", 0/8; "2R", 2/3; "7", 1/3; "8u", 1/3; "9R", 0/2; "10L", 0/4)
7) treatment effect: no prior treatment

No evidence of malignancy, "LC omentum"

AJCC pathologic stage: pT1b N2

<< Results of immunohistochemistry >>
C-erbB-2: Focal positive (2+, membranous in tumor cells(adenocarcinoma area))
C-MET : Negative in tumor cells
P53 : Positive in tumor cells (3+)
Ki-67 : Positive in 80% of tumor cells

[References]

1) EsoTODAY - Esophageal diseases

2) SmallTODAY - Small bowel diseases

3) ColonTODAY - Colorectal diseases

4) Dr. Sinn's LiverTODAY - Liver diseases