EndoTODAY | EndoATLAS | OPD

Parasite | Eso | Sto | Cancer | ESD

Boxim | DEX | Sono | Schedule

Home | Recent | Blog | Links


[Dr. Sinn's LiverTODAY 017 - Áö¹æ°£ ½ÉÆ÷Áö¾ö Áö»óÁß°è]

Previous | Next

Àú´Â Áö±Ý ¹Ì±¹ Washington D.C¿¡¼­ ¿­¸° ¹Ì±¹°£ÇÐȸ Emerging Trend Conference in NAFLD¿¡ ¿Í ÀÖ½À´Ï´Ù (Course Syllabus). Ç×°øºñ + ¼÷¹Úºñ + µî·Ïºñ (ÀÌÁØÇà ñÉ: Homepage¿¡¼­ È®ÀÎÇغ¸´Ï non-member 615 ´Þ·¯¿´½À´Ï´Ù)µîÀ» »ý°¢ÇÏ¸é ¸Å¿ì °íºñ¿ëÀÔ´Ï´Ù. Á¤½ÅÂ÷¸®°í µéÀ¸·Á°í ³ë·ÂÇßÀ¸³ª ½ÃÂ÷·Î ÀÎÇØ ½±Áö ¾Ê¾Ò½À´Ï´Ù.

Áö³­ Ãß°è°£ÇÐȸ ¶§ Áö»óÁ߰踦 ½ÃµµÇÏ¿´´Ù°¡ ¸¶¹«¸®ÇÏÁö ¸øÇÑ ÀûÀÌ ÀÖ½À´Ï´Ù (LiverTODAY 013). Áö»óÁß°è°¡ ¸Å¿ì ¾î·Á¿î ÀÏÀ̶ó´Â °ÍÀ» ¾Ë°ÔµÇ¾ú°í 2017³â º½ °£ÇÐȸ Ãá°è Single Topic Conference¿¡¼­´Â ½Ãµµµµ ÇÏÁö ¾Ê¾Ò½À´Ï´Ù^^. À̹ø¿¡´Â ¿­½ÉÈ÷ µéÀ¸·Á°í ³ë·ÂÇß´ø °­ÀÇ Áß °¡Àå Èï¹Ì·Î¿ü´ø °ÍÀ» ¼¼ °¡Áö¸¸ ¼±Á¤Çؼ­ Á¤¸®ÇØ º¸¾Ò½À´Ï´Ù.


1. Áö¹æ°£Àº Ç×»ó ³ª»Û°¡?

Stephen Caldwell ±³¼ö´ÔÀÌ °­ÀÇ (Mitochondria and Endoplasmic Reticulum in the Pathogenesis of NASH) Áß ¡°Áö¹æ°£ÀÌ º´À̶ó¸é, º´µç µ¿¹°ÀÇ °£À» À½½ÄÀ¸·Î Á¦°øÇÏ´Â °Í(ÇÁ¿Í±×¶ó)Àº ¸»µµ ¾ÈµÇ´Â ÀÏ¡±À̶ó¸ç °í¼Ò¸¦ ÁغñÇÏ°Ú´Ù´Â ºÐÀÌ ÀÖ¾ú´Ù°í Çϼ̽À´Ï´Ù. ±³¼ö´ÔÀº "°ÅÀ§´Â Áö¹æ°£Àº ÀÖÁö¸¸ Áö¹æ°£¿°Àº ¾øÀ¸´Ï, °í¼Ò°¡ ½ÇÆÐÇÒ °Í °°´Ù"°í ±Í¶äÇØ Á̴ּٰí ÇÕ´Ï´Ù.

Francesco Negro ±³¼ö´ÔÀº °­ÀÇ(Cardiovascular Diseases and NAFLD)¿¡¼­ À¯ÀüÀû º¯ÀÌ°¡ ÀÖ´Â »ç¶÷µéÀÌ NAFLD°¡ ´õ Àß »ý±âÁö¸¸ ½ÉÇ÷°ü À§ÇèÀº ¿ÀÈ÷·Á ³·°Ô °üÂûµÇ´Â ¿ª¼³ÀûÀÎ data¸¦ º¸¿©Áֽø鼭, NAFLD°¡ ½ÉÇ÷°ü°è »ç¸Á À§ÇèÀ» ³ôÀÌ´Â °ÍÀº ´Ü¼øÇÑ ¹®Á¦´Â ¾Æ´Ï¶ó´Â ÀÇ°ßÀ» Áּ̽À´Ï´Ù.


[½Åµ¿Çö comment]

Áö¹æ°£ÀÌ Ç×»ó ³ª»Ú³Ä, Á¤¸» º´Àû »óÅÂÀ̳Ĵµ¥´Â ³í¶õÀÇ ¿©Áö°¡ ÀÖ½À´Ï´Ù. ±Ù°Å´Â ¾øÁö¸¸ Áö¹æ°£ÀÌ adoptive mechanismÀÏ °¡´É¼ºµµ ¹èÁ¦ÇÒ ¼ö ¾ø½À´Ï´Ù. Áö¹æ°£ÀÇ ÀÚ¿¬°æ°ú µîÀÌ ¸íÈ®ÇÏÁö ¾ÊÀ¸¹Ç·Î °á·ÐÀ» ³»¸®±â´Â ¾î·Á¿î °Í °°½À´Ï´Ù. ÀúÈñÀÇ ¼±Çà ¿¬±¸¿¡¼­µµ (Sinn DH. Gastroenterology 2016) dyslipidemia°¡ Àִ ȯÀÚµé Áß Áö¹æ°£ÀÌ ¾ø´Ù°¡ Áö¹æ°£ÀÌ »ý±â¸é Áö¹æ°£ÀÌ »ý±âÁö ¾ÊÀº »ç¶÷º¸´Ù ¿ÀÈ÷·Á carotid atherosclerosis risk°¡ ³·´Ù°í ³ª¿Í ´çȲÇÑ ÀûÀÌ ÀÖ½À´Ï´Ù (Table 3).

¿Ö ÀÌ·¸°Ô ³ª¿ÔÀ»±î, ¿ì¿¬ÀÏ±î °í¹ÎÇÏ°í ÀÖ¾ú´Âµ¥, ¾î¼¸é Áö¹æÀ» °£¿¡ ÃàÀûÇÏ´Â °ÍÀÌ Ãʱ⿡´Â ½ÉÇ÷°ü°è À§ÇèÀ» ³·Ãâ ¼ö ÀÖ´Â ÀÎüÀÇ adoptive mechanismÀÏÁö ¸ð¸£°Ú´Ù´Â »ý°¢µµ µé¾ú½À´Ï´Ù. Áö¹æÀÌ °£¿¡ ÀϽÃÀûÀ¸·Î ÃàÀûµÈ´Ù°í ÀÎü¿¡ Å« ¹®Á¦°¡ µÇÁö´Â ¾ÊÀ¸´Ï±î¿ä. ÇÏÁö¸¸, Áö¹æ°£(steatosis)ÀÌ Áö¼ÓµÇ´Â °Í(persistent)Àº º´ÀûÀÎ »óȲÀÏ °¡´É¼ºÀÌ ³ô¾Æ º¸ÀÔ´Ï´Ù. ¶ÇÇÑ 'Áö¹æ°£¿°'ÀÌ º´Àû »óŶó´Â °Í¿¡´Â ÀÌ·ÐÀÇ ¿©Áö°¡ ¾ø´Â °Å °°½À´Ï´Ù.


2. The role of white adipose tissue in NASH (Vlad Ratziu)

Vlad Ratziu ±³¼ö´ÔÀº NAFLD¿¡¼­ adipose tissueÀÇ ¿ªÇÒ¿¡ ´ëÇØ °­Á¶Çϼ̽À´Ï´Ù. µ¿¹°½ÇÇèÀ¸·Î Áö¹æ°£À» ¸¸µé¸é Áö¹æÀÌ °£¿¡¸¸ ÃàÀûÀÌ µÇ´Â °ÍÀÌ ¾Æ´Ï¶ó´Â ´ç¿¬ÇÏÁö¸¸ Àر⠽¬¿î Çö»óÀ» Àϱú¿ö Áּ̽À´Ï´Ù. »ç¶÷ÀÇ °æ¿ìµµ NAFLD°¡ Àִ ȯÀÚ´Â Áö¹æÀÌ °£¿¡¸¸ ÀÖ´Â °ÍÀÌ ¾Æ´Ï°í, ´Ù¸¥ °÷¿¡µµ ÃàÀûµË´Ï´Ù. Subcutaneous fat ÀÎÁö visceral fatÀÎÁö, ectopic fat deposition À§Ä¡¿¡ µû¶ó (pancrease, renal, cardiac) ¿µÇâÀÌ ´Ù¸¨´Ï´Ù. Morbid obeseÇÑ È¯ÀÚµéÀ» bariatric surgery¸¦ ÇÑ data¸¦ º¸¿©Áּ̽À´Ï´Ù (Bedossa P. Gut 2016). ³í¹® °á·Ð Áß ÀϺÎÀÔ´Ï´Ù ¡°A shift of fat storage from subcutaneous to visceral adipose tissue compartment is associated with liver damages. ¡° Fat storage shift¿Í ¿¬°üµÈ °¡Àå Áß¿äÇÑ ÀÎÀÚ´Â ¿¬·ÉÀ̾ú½À´Ï´Ù. ³ªÀ̵é¸é¼­ »ìÂî´Â °ÍÀº Àþ¾î¼­ »ìÂî´Â °Í¿¡ ºñÇØ '°£ÀÇ °Ç°­' Ãø¸é¿¡¼­ ´õ ¾ÈÁÁÀº À§Ä¡¿¡ Áö¹æħÂøÀÌ ÀϾ¹Ç·Î ´õ¿í ³ª»Ú´Ù´Â ¶æÀÔ´Ï´Ù. ³ªÀ̵é¼ö·Ï ÀûÁ¤ üÁß À¯Áö°¡ Áß¿äÇÕ´Ï´Ù.


3. Will the epidemic of NAFLD be responsible for the future burden of HCC? (Elisabetta Bugianesi, Italy)

Áö¹æ°£°ú ¿¬°üµÈ °£¾ÏÀº hot issueÀÔ´Ï´Ù. Bugianesi ±³¼ö´ÔÀÇ °­ÀǸ¦ ³ª¸§ ¿ä¾àÇØ º¸¾Ò½À´Ï´Ù.


[Epilogue]

Younossi ±³¼ö´ÔÀÌ 20¿©³â Àü ù fatty liver ½ÉÆ÷Áö¿ò¿¡¼­´Â µî·ÏÀοøÀÌ 50¸íµµ µÇÁö ¾Ê¾Ò´Âµ¥, Áö±ÝÀº 750¸í ÀÌ»ó µî·ÏÇÏ¿© °Ý¼¼Áö°¨À» ´À³¤´Ù°í ¸»¾¸Çϼ̽À´Ï´Ù. Á¤¸» ¸¹Àº »ç¶÷µéÀÌ ¿­½ÉÈ÷ °øºÎÇÏ´Â °ÍÀ» º¸°Ô µÇ¾ú½À´Ï´Ù. Àúµµ Å« ¸¶À½¸Ô°í °øºÎÇÏ·¯ °¬´Âµ¥, ±ä ºñÇà(13½Ã°£)°ú ½ÃÂ÷·Î ¸Å¿ì ÇÇ°ïÇß½À´Ï´Ù.

¸Ö¸® °¡Áö ¾Ê¾Æµµ ¾ÉÀº ÀÚ¸®¿¡¼­ °£°ü·Ã °øºÎ¸¦ ÇÒ ¼ö ÀÖ´Â ÁÁÀº ÀÚ·á½ÇÀÌ ÀÖ½À´Ï´Ù. ´ëÇÑ °£ÇÐȸ ±³À°ÀÚ·á½ÇÀÔ´Ï´Ù(http://www.kasl.org/bbs/?code=academy). À۳⠰£ÇÐȸ Single Topic Conference¿¡¼­ ÁøÇàµÈ Áö¹æ°£ °ü·Ã ´Ù¾çÇÑ °­ÀÇ ÀÚ·á°¡ ¸ðµÎ ¿Ã¶ó¿Í ÀÖ½À´Ï´Ù. ´©±¸³ª º¸½Ç ¼ö ÀÖ½À´Ï´Ù. Çѹø »ìÆ캸½Ç °ÍÀ» ÃßõÇÕ´Ï´Ù.


[References]

1) EsoTODAY - Esophageal diseases

2) SmallTODAY - Small bowel diseases

3) ColonTODAY - Colorectal diseases

4) Dr. Sinn's LiverTODAY - Liver diseases

© ¼º±Õ°ü´ëÇб³ ÀÇ°ú´ëÇÐ »ï¼º¼­¿ïº´¿ø ¼ÒÈ­±â³»°ú ½Åµ¿Çö